abstract：:Cardiac adaptation to aerobic exercise training includes improved cardiomyocyte contractility and calcium handling. Our objective was to determine whether cytosolic calcium/calmodulin-dependent kinase II and its downstream targets are modulated by exercise training. A six-week aerobic interval training program by trea...

journal_title：Journal of molecular and cellular cardiology

authors： Kemi OJ,Ellingsen O,Ceci M,Grimaldi S,Smith GL,Condorelli G,Wisløff U

更新日期：2007-09-01 00:00:00

abstract：:The loss of cardiomyocytes by apoptosis and the subsequent replacement by fibrous connective tissues are important features of cardiac remodeling in adult heart disease. In children with CHD, however, the cellular and molecular mechanisms of heart failure have not yet been fully understood because of the anatomical an...

journal_title：Journal of molecular and cellular cardiology

authors： Sato H,Shiraishi I,Takamatsu T,Hamaoka K

更新日期：2007-09-01 00:00:00

abstract：:CD34+ progenitor cells hold promise for therapeutic neovascularization in various settings. In this study, the role of human peripheral blood CD34+ cells in neovascularization and inflammatory cell recruitment was longitudinally studied in vivo. Human CD34+ cells were incorporated in Matrigel, implanted subcutaneously...

journal_title：Journal of molecular and cellular cardiology

authors： van der Strate BW,Popa ER,Schipper M,Brouwer LA,Hendriks M,Harmsen MC,van Luyn MJ

更新日期：2007-06-01 00:00:00

abstract：:The existing literature indicates a crucial role of p38 MAP (mitogen-activated protein) kinase (p38MAPK) and its downstream target MAPKAP kinase 2 (MK2) in ischemic preconditioning (IPC). Accordingly, deletion of MK2 gene should abolish the cardioprotective ability of IPC. Interestingly, we were able to partially prec...

journal_title：Journal of molecular and cellular cardiology

authors： Nagy N,Shiroto K,Malik G,Huang CK,Gaestel M,Abdellatif M,Tosaki A,Maulik N,Das DK

更新日期：2007-05-01 00:00:00

abstract：:The specialized cardiac conduction system (CCS) consists of the sinoatrial node (SAN) and the atrioventricular (AV) conduction system (AVCS), which includes proximal (AV node, bundle of His and bundle branches) and distal (Purkinje fibers) components. In four CCS marker mice [two transgenic (cGATA6|lacZ, CCS|lacZ) and...

journal_title：Journal of molecular and cellular cardiology

authors： Viswanathan S,Burch JB,Fishman GI,Moskowitz IP,Benson DW

更新日期：2007-05-01 00:00:00

abstract：:Cardioprotection and preconditioning mediated via G-protein-coupled receptors may be lost or impaired with advancing age, limiting ischemic tolerance and the ability to pharmacologically protect older hearts from ischemic injury. Our preliminary findings indicated a loss of delta-opioid receptor-mediated protection in...

journal_title：Journal of molecular and cellular cardiology

authors： Peart JN,Gross ER,Headrick JP,Gross GJ

更新日期：2007-05-01 00:00:00

abstract：:The aim of this study was to examine whether short- and long-term gene transfer of Ca(2+) handling proteins restore left ventricular (LV) mechanoenergetics in aortic banding-induced failing hearts. Aortic-banded rats received recombinant adenoviruses carrying sarcoplasmic reticulum Ca(2+)-ATPase (SERCA2a) (Banding+SER...

journal_title：Journal of molecular and cellular cardiology

authors： Sakata S,Lebeche D,Sakata N,Sakata Y,Chemaly ER,Liang LF,Tsuji T,Takewa Y,del Monte F,Peluso R,Zsebo K,Jeong D,Park WJ,Kawase Y,Hajjar RJ

更新日期：2007-04-01 00:00:00

abstract：:We have previously shown that domains involved in binding of protein kinase C (PKC) isozymes to their respective anchoring proteins (RACKs) and short peptides derived from these domains are PKC isozyme-selective antagonists. We also identified PKC isozyme-selective agonists, named psiRACK peptides, derived from a sequ...

journal_title：Journal of molecular and cellular cardiology

authors： Liron T,Chen LE,Khaner H,Vallentin A,Mochly-Rosen D

更新日期：2007-04-01 00:00:00

abstract：:Diabetic cardiomyopathy has been documented as an underlying etiology of heart failure (HF) among diabetics. Although oxidative stress has been proposed to contribute to diabetic cardiomyopathy, much of the evidence lacks specificity. Furthermore, whether alterations occur at the cardiac proteome level in diabetic car...

journal_title：Journal of molecular and cellular cardiology

authors： Hamblin M,Friedman DB,Hill S,Caprioli RM,Smith HM,Hill MF

更新日期：2007-04-01 00:00:00

abstract：:Frequency-dependent acceleration of relaxation (FDAR) is an important intrinsic mechanism that allows for diastolic filling of the ventricle at higher heart rates, yet its molecular mechanism is still not understood. Previous studies showed that FDAR is dependent on functional sarcoplasmic reticulum (SR) and can be ab...

journal_title：Journal of molecular and cellular cardiology

authors： Huke S,Bers DM

更新日期：2007-03-01 00:00:00

abstract：:To demonstrate a direct protective effect of propofol on myocardial contractile performance during an ischemic episode and investigate underlying mechanisms, isolated adult rat ventricular cardiomyocytes were subjected for 2 h to (i) ischemic medium containing 2-deoxyglucose (20 mM), gassed with 100% N(2) at pH 6.4, (...

journal_title：Journal of molecular and cellular cardiology

authors： McDermott BJ,McWilliams S,Smyth K,Kelso EJ,Spiers JP,Zhao Y,Bell D,Mirakhur RK

更新日期：2007-03-01 00:00:00

abstract：:The activation of NO/cGMP pathways can induce pro-apoptotic pathways in cardiomyocytes although only a small number of cardiomyocytes fulfill the criteria of apoptosis. The same pathways reduce the contractile performance of cardiomyocytes. In the present study, we tested the hypothesis that exposure of cells to NO/cG...

journal_title：Journal of molecular and cellular cardiology

authors： Tastan H,Abdallah Y,Euler G,Piper HM,Schlüter KD

更新日期：2007-02-01 00:00:00

abstract：:Clinical studies suggest increased arrhythmia risk associated with cell therapy for myocardial infarction (MI); however, the underlying mechanisms are poorly understood. We hypothesize that the degree of electrical viability in the infarct and border zone associated with skeletal myoblast (SKMB) or mesenchymal stem ce...

journal_title：Journal of molecular and cellular cardiology

authors： Mills WR,Mal N,Kiedrowski MJ,Unger R,Forudi F,Popovic ZB,Penn MS,Laurita KR

更新日期：2007-02-01 00:00:00

abstract：:Mild or low doses of oxidants are known to prime cells towards resistance against further damage. In cardiomyocytes, we found that pretreatment with 100 microM H(2)O(2) prevents the cells from apoptosis induced by doxorubicin (Dox). Affymetrix microarray analyses of 28,000 genes reveal that H(2)O(2) treated cells redu...

journal_title：Journal of molecular and cellular cardiology

authors： Purdom-Dickinson SE,Lin Y,Dedek M,Morrissy S,Johnson J,Chen QM

更新日期：2007-01-01 00:00:00

abstract：:Sphingomyelin breakdown product ceramide has recently been found to induce an adaptive response and reduce myocardial ischemia/reperfusion injury. Since activation of MAP kinases plays an essential role in myocardial adaptation to ischemic stress and since ceramide is involved in lipid raft formation where MAP kinases...

journal_title：Journal of molecular and cellular cardiology

authors： Das M,Cui J,Das DK

更新日期：2007-01-01 00:00:00

abstract：:Cardiac-specific transgenesis in the mouse is widely used to study the basic biology and chemistry of the heart and to model human cardiovascular disease. A fundamental difference between mouse and human hearts is the background motor protein: mouse hearts contain predominantly the alphaalpha-myosin heavy chain (MyHC)...

journal_title：Journal of molecular and cellular cardiology

authors： Hoyer K,Krenz M,Robbins J,Ingwall JS

更新日期：2007-01-01 00:00:00

abstract：:Experimental evidence has emerged that myocardial ischemic preconditioning can prime the mitochondria into a "stress-resistant state", so that cell death is reduced following prolonged severe ischemia and reperfusion. Using a swine model of chronically ischemic myocardium, we tested the hypothesis that mitochondria wi...

journal_title：Journal of molecular and cellular cardiology

authors： McFalls EO,Sluiter W,Schoonderwoerd K,Manintveld OC,Lamers JM,Bezstarosti K,van Beusekom HM,Sikora J,Ward HB,Merkus D,Duncker DJ

更新日期：2006-12-01 00:00:00

abstract：:Connexin40 (Cx40) and connexin45 (Cx45) are involved in both cardiac morphogenesis and propagation of electrical activity. We found that Cx40/Cx45 double deficiency (Cx40(-/-)/Cx45(+/-)) causes a variety of cardiac defects leading to high mortality during embryonic development and at birth. The majority of Cx40(-/-)/C...

journal_title：Journal of molecular and cellular cardiology

authors： Krüger O,Maxeiner S,Kim JS,van Rijen HV,de Bakker JM,Eckardt D,Tiemann K,Lewalter T,Ghanem A,Lüderitz B,Willecke K

更新日期：2006-11-01 00:00:00

abstract：:Increasing bodies of evidence indicate that reactive oxygen species (ROS) produced by mitochondria and other sources play an essential role in mediating ventricular remodeling after myocardial infarction and the development of heart failure. Antioxidants scavenge ROS, thereby maintaining the reduced environment of cel...

journal_title：Journal of molecular and cellular cardiology

authors： Ago T,Sadoshima J

更新日期：2006-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent agonist of cell growth that also stimulates Na(+)/H(+) exchanger isoform 1 (NHE-1) activity. It was hypothesized that the increase in intracellular Na(+) ([Na(+)](i)) mediated by NHE-1 activity may induce the reverse mode of Na(+)/Ca(2+) exchanger (NCX(rev)) increasing intracellular Ca(...

journal_title：Journal of molecular and cellular cardiology

authors： Dulce RA,Hurtado C,Ennis IL,Garciarena CD,Alvarez MC,Caldiz C,Pierce GN,Portiansky EL,Chiappe de Cingolani GE,Camilión de Hurtado MC

更新日期：2006-11-01 00:00:00

abstract：:Cardiac hypertrophy is an adaptive process against increased work loads; however, hypertrophy also presents substrates for lethal ventricular arrhythmias, resulting in sudden arrhythmic deaths that account for about one third of deaths in cardiac hypertrophy. To maintain physiological cardiac function in the face of i...

journal_title：Journal of molecular and cellular cardiology

authors： Furukawa T,Kurokawa J

更新日期：2006-11-01 00:00:00

abstract：:Caloric restriction extends longevity and reduces the onset of chronic disease in many animal models. Recently, caloric restriction was shown in humans to be associated with lower blood pressure, decreased systemic inflammation, and improved cardiac diastolic parameters. However, the causation and mechanisms of calori...

journal_title：Journal of molecular and cellular cardiology

authors： Seymour EM,Parikh RV,Singer AA,Bolling SF

更新日期：2006-10-01 00:00:00

abstract：:Estrogen receptor alpha (ERalpha) is present in the heart consistent with estrogen-induced modulation of cardiac function by genomic and non-genomic mechanisms, and with estrogen-mediated cardioprotective effects. We show that, in heart from adult male rats, ERalpha is detected mainly as two distinct isoforms: (i) a a...

journal_title：Journal of molecular and cellular cardiology

authors： Ropero AB,Eghbali M,Minosyan TY,Tang G,Toro L,Stefani E

更新日期：2006-09-01 00:00:00

abstract：:Atrial fibrillation (AF) causes myocyte stress by inducing structural changes, predominantly myolysis, which is related to the progression of AF. As heat shock proteins (Hsp) protect against cellular stress, their efficacy in preventing myolysis was investigated in a tachy-paced cell model for AF and in patients with ...

journal_title：Journal of molecular and cellular cardiology

authors： Brundel BJ,Henning RH,Ke L,van Gelder IC,Crijns HJ,Kampinga HH

更新日期：2006-09-01 00:00:00

abstract：:Leptin is a 16 kDa product of the obesity gene secreted primarily by adipocytes. We recently identified cardiomyocytes as a target for the direct hypertrophic effects of leptin and suggested that leptin may be a biological link between obesity and cardiovascular pathologies. Activation of the renin-angiotensin and end...

journal_title：Journal of molecular and cellular cardiology

authors： Rajapurohitam V,Javadov S,Purdham DM,Kirshenbaum LA,Karmazyn M

更新日期：2006-08-01 00:00:00

abstract：:Acute right ventricular (RV) failure following pulmonary embolism (PE) is a strong predictor of poor clinical outcome. Present studies test for an association between RV failure from experimental PE, inflammation, and upregulated chemokine expression. Additional experiments test if neutrophil influx contributes to RV ...

journal_title：Journal of molecular and cellular cardiology

authors： Watts JA,Zagorski J,Gellar MA,Stevinson BG,Kline JA

更新日期：2006-08-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) has protean manifestations, including the regulation of growth and migration, in many cell types. We have previously reported that PDGF-BB induces the accumulation of monocyte chemoattractant protein (MCP)-1 mRNA in smooth muscle cells (SMC), in large part due to an increase in mR...

journal_title：Journal of molecular and cellular cardiology

authors： Liu B,Poon M,Taubman MB

更新日期：2006-07-01 00:00:00

abstract：:This study examined the hypothesis that the prediabetic metabolic syndrome alters expression, phosphorylation state and binding affinity of cardiac RyR2. Real-time PCR and Western blot analysis were used to assess mRNA and protein expression in the left ventricle, right ventricle and right atrium from control (n=5) an...

journal_title：Journal of molecular and cellular cardiology

authors： Dincer UD,Araiza A,Knudson JD,Shao CH,Bidasee KR,Tune JD

更新日期：2006-07-01 00:00:00

abstract：:Growing evidence suggests that the beta1-adrenoceptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated cardiomyopathy. The aim of this study is to further study the effect of specific immunoabsorption of anti-beta1-adrenoceptor autoantibodies on cardiac structure and f...

journal_title：Journal of molecular and cellular cardiology

authors： Matsui S,Larsson L,Hayase M,Katsuda S,Teraoka K,Kurihara T,Murano H,Nishikawa K,Fu M

更新日期：2006-07-01 00:00:00

abstract：:Heat shock protein 27 (Hsp27) and alpha B-crystallin (alphaBC) are small heat shock proteins that stabilize the myofilament during stress. We utilized two-dimensional gel electrophoresis (2-DE), phospho-fluorescence staining, titanium dioxide (TiO(2)) phosphopeptide purification and mass spectrometry (MS) to fully cha...

journal_title：Journal of molecular and cellular cardiology

authors： White MY,Hambly BD,Jeremy RW,Cordwell SJ

更新日期：2006-06-01 00:00:00

abstract：:Application of ultrasound-mediated destruction of microbubbles (US + Bubble) to skeletal muscle creates capillary ruptures leading to leakage of the cell components. We studied whether US + Bubble combined with bone-marrow-derived mononuclear cells (BM-MNCs) infusion enables the targeted delivery of endothelial-lineag...

journal_title：Journal of molecular and cellular cardiology

authors： Zen K,Okigaki M,Hosokawa Y,Adachi Y,Nozawa Y,Takamiya M,Tatsumi T,Urao N,Tateishi K,Takahashi T,Matsubara H

更新日期：2006-06-01 00:00:00

abstract：:Our laboratory has previously shown that adenoviral-mediated overexpression of Galphaq in neonatal rat ventricular cardiomyocytes increases the phosphorylation of Akt, a well-established anti-apoptotic effector. As demonstrated here, Galphaq expression protects cardiomyocytes against apoptosis induced by treatment wit...

journal_title：Journal of molecular and cellular cardiology

authors： Howes AL,Miyamoto S,Adams JW,Woodcock EA,Brown JH

更新日期：2006-05-01 00:00:00

abstract：:Our previous studies showed that homocysteine (Hcy) reduces endothelial progenitor cell (EPC) numbers and impairs functional activity. However, the mechanisms by which Hcy reduces EPCs numbers and activity remain to be determined. Recent studies have demonstrated that reduced EPCs numbers and activity was associated w...

journal_title：Journal of molecular and cellular cardiology

authors： Zhu JH,Chen JZ,Wang XX,Xie XD,Sun J,Zhang FR

更新日期：2006-05-01 00:00:00

abstract：:We previously reported that transgenic (TG) mice with cardiac-restricted alpha(1A)-adrenergic receptor (alpha(1A)-AR)-overexpression showed enhanced contractility, but no hypertrophy. Since chronic inotropic enhancement may be deleterious, we investigated if long-term, cardiac function and longevity are compromised. a...

journal_title：Journal of molecular and cellular cardiology

authors： Chaulet H,Lin F,Guo J,Owens WA,Michalicek J,Kesteven SH,Guan Z,Prall OW,Mearns BM,Feneley MP,Steinberg SF,Graham RM

更新日期：2006-04-01 00:00:00

abstract：:We measured mitochondrial NADH autofluorescence or Ca(2+) using Rhod-2, simultaneously with cell shortening in isolated guinea-pig ventricular myocytes. When both frequency and amplitude of twitch shortening (work intensity) were increased by raising stimulus frequency in incremental steps from 0.1 to 3.3 Hz, the stea...

journal_title：Journal of molecular and cellular cardiology

authors： Jo H,Noma A,Matsuoka S

更新日期：2006-03-01 00:00:00

abstract：:Atrial cardiac myocytes secrete the vasoactive hormone atrial natriuretic peptide (ANP) by both constitutive and regulated exocytotic fusion of ANP-containing large dense core vesicles (LDCV) with the sarcolemma. Detailed information, however, regarding the identity and function of specific membrane fusion proteins (S...

journal_title：Journal of molecular and cellular cardiology

authors： Peters CG,Miller DF,Giovannucci DR

更新日期：2006-03-01 00:00:00

abstract：:Nitric oxide plays a crucial role in myocardial ischemia reperfusion injury as well as in myocardial adaptation to ischemic stress. To understand the dichotomy of nitric oxide behavior in the ischemic myocardium, isolated rat hearts were subjected to ischemia/reperfusion protocol. The tissue contents of sphingomyelin ...

journal_title：Journal of molecular and cellular cardiology

authors： Der P,Cui J,Das DK

更新日期：2006-02-01 00:00:00

abstract：:Understanding the inflammatory response to myocardial ischemia is an important part of achieving the elusive clinical goal of perfect myocardial protection. While it is established that estrogen affects the chronic inflammatory processes of coronary atherosclerosis, the effects of estrogen on acute myocardial proinfla...

journal_title：Journal of molecular and cellular cardiology

authors： Wang M,Tsai BM,Reiger KM,Brown JW,Meldrum DR

更新日期：2006-02-01 00:00:00

abstract：:Recent improvements in survival from AIDS have been accompanied by an increased recognition of the potential importance of other manifestations of HIV infection, including cardiomyopathy. Mechanisms responsible for HIV cardiomyopathy are unknown, but may include direct effects of HIV proteins on the heart. We previous...

journal_title：Journal of molecular and cellular cardiology

authors： Kan H,Xie Z,Finkel MS

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to investigate the effects of aging on the profile of myocardial substrate utilization and cardiac function using a physiological profile of substrates. Hearts from 6-, 15- and 24-month male Wistar rats were perfused in the isovolumic Langendorff mode, with physiological concentrations of 13C...

journal_title：Journal of molecular and cellular cardiology

authors： Sample J,Cleland JG,Seymour AM

更新日期：2006-01-01 00:00:00